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Next Generation Nanosolutions for Cancer Treatment and Diagnosis

July-September 2008, Volume 03, Number 3
Jerry S.H. Lee, Jianjun Cheng and Kelly Y. Kim
Center for Strategic Scientific Initiatives, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

This review describes several state of the art advances made in the field of cancer nanotechnology that bring the science closer to clinical realization for application in disease treatment and diagnosis. For therapeutic delivery, in vivo strategies to improve the biodistribution, tumor penetration, and cellular uptake of nanocarriers are discussed, including the precise control of formulation and conjugation of targeting agents. We highlight recently developed novel nanosolutions that specifically address cancer metastasis. We also describe in detail the promising use of nanotechnologies for in vitro diagnostics on tissue section samples, an area that appears to be ready for clinical application in the near future. Finally, we discuss emerging discoveries on the unique biophysical properties of cancer that hold promise for paradigm shifts in future cancer diagnosis and treatment strategies as this field continues to mature.

Key words:
Nanotechnology. Nanocarriers. Cancer targeting. Drug delivery. Raman spectroscopy. Multiplex spectral imaging. Cell mechanics.
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